Information on routes and fares to Greece is available from RailEurope. The rail network in Greece is limited to the mainland with a fairly skeletal system and services tend to be slow but inexpensive. Inter-city services are faster but more expensive. Overnight sleeper services are available on the Thessaloniki-Athens and Thessaloniki-Alexandroupoli routes.

Travelling to Greece is expensive, and, for example, London to Athens takes around three days and is through France, Switzerland and Italy and then by ferry from Brindisi or Bari to Patra. The only other route is through former Yugoslavia and the train travels via Hungary, Belgrade and Skopje to Thessaloniki.

The Greek train network is operated by OSE and Athens forms the hub of the system. A northbound line from Larissis station links the city with Thessaloniki with branch lines to Chalkida, Volos, Karditsa, Trikala and Kalampaka; and Edessa and Kozani. The southern narrow gauge railway runs from Athens Peloponnisou station to towns in the Peloponnese linking Athens with Patra and Pyrgos or via Argos and Tripoli.

It's a 15 minute walk to Omonia from both of the above stations.